Lot-et-Garonne is one of the original 83 departments created during the French Revolution on March 4, 1790. It was created from part of the provinces of Guyenne and Gascogne. Some of the original southeastern cantons were separated from it in 1808 to form the department of Tarn-et-Garonne.

Lot-et-Garonne is part of the current region of Aquitaine and is surrounded by the departments of Lot, Tarn-et-Garonne, Gers, Landes, Gironde, and Dordogne.

Lot-et-Garonne is one of the original 83 departments created during the French Revolution on March 4, 1790. It was created from part of the provinces of Guyenne and Gascogne. Some of the original southeastern cantons were separated from it in 1808 to form the department of Tarn-et-Garonne.

Lot-et-Garonne is part of the current region of Aquitaine and is surrounded by the departments of Lot, Tarn-et-Garonne, Gers, Landes, Gironde, and Dordogne.